Related Experiment Videos
Integrins in human anterior chamber angle
K Tervo1, T Päällysaho, I Virtanen
1Department of Anatomy, University of Helsinki, Finland.
Background:
Integrins, which are composed of an alpha and beta subunit, are capable of binding to a number of extracellular matrix proteins and, hence, affect cell adhesion and proliferation.
Methods:
The distribution of the integrin beta (beta 1, beta 3-beta 5) and alpha (alpha 1-6 and alpha v) subunits in human anterior chamber angle was studied in eyes from subjects aged 9 months to 81 years using the indirect immunofluorescence technique.
Results:
Immunoreaction for the beta 1 subunit was found throughout the trabecular meshwork (TM), in the cribriform layer, and in the endothelial lining of Schlemm's canal (SC). Labelling for the alpha 3 subunit was found in the TM and the cribriform layer only. In infant eyes the alpha 5 subunit was present in all three areas with the highest concentration in the cribriform layer, whereas no reaction was observed in adult eyes. The alpha 6 subunit was localized to the endothelium of SC only. Immunoreaction for the alpha v subunit was present in the TM and the cribriform layer of infants and young adults.
Conclusion:
The present results suggest the presence of several integrin heterodimers, acting as potential receptors for laminin, collagen, fibronectin, and vitronectin, in the anterior chamber angle.