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Related Experiment Videos

Relation between plasma oestrone and oestradiol and climacteric symptoms

J D Hutton, H S Jacobs, M A Murray

    Lancet (London, England)
    |April 1, 1978
    PubMed
    Summary

    Postmenopausal women experiencing superficial dyspareunia (painful intercourse) have lower plasma oestradiol levels compared to symptomless women. This finding suggests oestradiol, not oestrone, may be key for treating certain menopausal symptoms.

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    Area of Science:

    • Endocrinology
    • Menopause Research
    • Women's Health

    Background:

    • Menopause is associated with declining oestrogen levels, leading to various symptoms.
    • Superficial dyspareunia and hot flushes are common climacteric symptoms.
    • The relationship between specific menopausal symptoms and circulating oestrogen levels requires further clarification.

    Purpose of the Study:

    • To investigate plasma oestrone and oestradiol-17beta levels in postmenopausal women.
    • To compare oestrogen levels in women with superficial dyspareunia and/or flushes versus symptomless women.
    • To determine the association between plasma oestrogen and specific menopausal symptoms.

    Main Methods:

    • Blood samples were collected at 20-30 minute intervals for up to 24 hours from 26 postmenopausal or ovariectomised women.

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  • Participants were similar in age, weight, and years since menopause/operation.
  • Plasma concentrations of oestrone and oestradiol-17beta were quantified.

    • Main Results:

    • Women with superficial dyspareunia exhibited significantly lower mean plasma oestradiol concentrations compared to symptomless women.
    • No significant difference in plasma oestrone levels was observed between women with dyspareunia and symptomless women.
    • Hot flushes were not found to be related to plasma oestrogen levels.

    Conclusions:

    • Lower plasma oestradiol, but not oestrone, is associated with superficial dyspareunia in postmenopausal women.
    • These findings may inform the optimal oestrogen dosage for managing climacteric symptoms.
    • Further research is warranted to explore the role of oestradiol in dyspareunia and its treatment.