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A proposed blood circulation model for Reference Man

R W Leggett1, L R Williams

  • 1Health Sciences Research Division, Oak Ridge National Laboratory, TN 37831-6480, USA.

Health Physics
|August 1, 1995
PubMed
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This study presents a dynamic blood circulation model for the revised Reference Man, predicting radionuclide distribution after injection. The model accounts for organ blood volumes and transit times for improved accuracy in radiological protection.

Area of Science:

  • Radiological physics
  • Biomedical engineering
  • Human physiology

Background:

  • The International Commission on Radiological Protection (ICRP) is revising its Reference Man model.
  • Accurate modeling of blood circulation is crucial for predicting radionuclide behavior in the body.
  • Previous work established reference values for blood volumes and cardiac output.

Purpose of the Study:

  • To unify proposed features of the revised Reference Man into a dynamic blood circulation model.
  • To demonstrate the model's utility in predicting radionuclide distribution after injection or absorption.
  • To incorporate tissue-dependent extraction and plasma return of substances.

Main Methods:

  • Developed a dynamic blood circulation model based on first-order transfer between blood pools.

Related Experiment Videos

  • Partitioned total blood volume into 24 organs/tissues and circulatory components.
  • Incorporated delay times based on mean transit times for initial circulation passes.

    • Main Results:

    • The unified model predicts the distribution of short-lived radionuclides in the body.
    • The model simulates the movement and dispersal of injected materials.
    • It allows for consideration of incomplete and tissue-specific extraction during circulation.

    Conclusions:

    • The dynamic blood circulation model provides a framework for the revised ICRP Reference Man.
    • This model enhances the prediction of radionuclide behavior for radiological dose assessments.
    • It offers a more realistic representation of substance transport and distribution in the human circulatory system.