Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental determinants at the mammalian optic chiasm

R W Guillery1, C A Mason, J S Taylor

  • 1Department of Human Anatomy, University of Oxford, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Percutaneous nephrostomy catheter-related infections in patients with gynaecological cancers: a multidisciplinary algorithmic approach.

The Journal of hospital infection·2023
Same author

Montaigne and Medicine.

Annals of medical history·2021
Same author

Montaigne and Medicine.

Annals of medical history·2021
Same author

Montaigne and Medicine.

Annals of medical history·2021
Same author

Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000-2016.

The British journal of dermatology·2021
Same author

Enterobacter cloacae pericardial effusion in a frail elderly patient.

BMJ case reports·2015

The mammalian optic chiasm

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Ophthalmology

Background:

  • The optic chiasm is crucial for visual processing, where retinal axons cross.
  • Its adult structure is a simplified view; development involves complex axon rearrangements.
  • Nonprimate development shows less strict naso-temporal segregation initially.

Purpose of the Study:

  • To detail the dynamic developmental stages of the optic chiasm.
  • To explore the molecular and cellular cues guiding axon pathfinding.
  • To understand the species-specific and genetically influenced variations in optic chiasm formation.

Main Methods:

  • Observation of axon behavior in vitro and in vivo.
  • Analysis of developmental stages across species.

Related Experiment Videos

  • Investigation of genetic mutants and experimental modifications.

    • Main Results:

    • Axons reorganize order (retinotopic to chronotopic and back) during development.
    • Molecular and cellular cues are present in the retina, axons, and pathway.
    • Candidate molecules' roles in pathway determination remain unclear.

    Conclusions:

    • Optic chiasm development is a complex, multi-stage process.
    • Investigating these dynamic changes offers insights into molecular cue functions.
    • Experimental models facilitate the study of visual pathway formation.