Effect of vitamin E on adhesion formation

This study investigated the effects of vitamin E on adhesion formation and fibrosis. Forty-eight adult, virgin, female Sprague-Dawley rats were divided equally into two groups, one of which received 300 mIU/kg vitamin E orally in their daily diet in comparison with the control group, which received the vehicle only. Laparotomy was performed and the uterine horns identified. Denuding of the serosa was performed over a segment of the right horn; bipolar coagulation over a similar area on the left horn was performed. Following the procedure the animals continued on the same diet for three weeks. They were then killed, the adhesions were graded, and microscopic evaluation for fibrosis was accomplished. Although there was a trend of less fibrosis with vitamin E, there was no statistically significant difference, nor was there a difference with respect to a reduction in adhesion formation.