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Further evidence of a dose-response threshold for haloperidol in psychosis
C K Stone1, D L Garve, J Griffith
1Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas, USA.
The American Journal of Psychiatry
|August 1, 1995
Abstract
Objective:
The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response.
Method:
During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol.
Results:
No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected.
Conclusions:
Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.