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Related Experiment Videos

Apoptosis in thyroid diseases: a histochemical study

C Tanimoto1, S Hirakawa, H Kawasaki

  • 1Third Department of Internal Medicine, Okayama Medical School, Japan.

Endocrine Journal
|April 1, 1995
PubMed
Summary
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Apoptosis, or programmed cell death, occurs in Hashimoto's thyroiditis and thyroid cancer. In Graves' disease, bcl-2 expression appears to prevent apoptosis, suggesting different mechanisms in thyroid diseases.

Area of Science:

  • Endocrinology
  • Cell Biology
  • Pathology

Background:

  • Apoptosis is a critical mechanism in both normal physiological processes and disease states.
  • Understanding apoptosis in thyroid disorders is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the presence and significance of apoptosis in various thyroid conditions.
  • To compare apoptotic markers in Hashimoto's thyroiditis, thyroid cancer, Graves' disease, and normal thyroid tissue.

Main Methods:

  • Utilized immunohistochemistry and in situ end-labeling of fragmented DNA (ISEL) to detect apoptotic phenomena.
  • Examined thyroid tissue samples from patients with different thyroid diseases and normal controls.

Main Results:

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  • Fragmented DNA and the apoptosis-associated antigen LeY were detected in Hashimoto's thyroiditis and thyroid cancer tissues.
  • Graves' disease tissues showed LeY and bcl-2 oncoprotein expression, but lacked ISEL-positive cells.
  • Normal thyroid tissues did not exhibit ISEL or LeY staining, while Fas antigen was broadly expressed.

Conclusions:

  • Apoptosis is actively occurring in Hashimoto's thyroiditis and thyroid cancer.
  • Bcl-2 oncoprotein expression in Graves' disease may inhibit or overcome the apoptotic process.
  • Further research is needed to determine the clinical significance of Fas antigen expression in thyroid tissues.