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Auditory input to the pedunculopontine nucleus: I. Evoked potentials
N B Reese1, E Garcia-Rill, R D Skinner
1Department of Physical Therapy, University of Central Arkansas, Conway 72035, USA.
Brain Research Bulletin
|January 1, 1995
Summary
The pedunculopontine nucleus (PPN) generates auditory-evoked potentials in decerebrate cats and rats. These midbrain potentials are similar to those in intact animals, suggesting PPN
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Sleep and Wakefulness Research
Background:
- The pedunculopontine nucleus (PPN) plays a role in sleep-wake control, arousal, and motor functions.
- The PPN is also implicated in generating the P1 middle-latency auditory-evoked potential (AEP).
Purpose of the Study:
- To investigate the topographical distribution, threshold, and response properties of depth-recorded potentials after auditory click stimulation.
- To determine the presence of P1-like AEPs in the midbrain of decerebrate cats and rats.
Main Methods:
- Experiments were conducted in decerebrate cat and rat preparations.
- Depth-recorded potentials were analyzed following auditory click stimulation.
- Somatosensory-evoked potentials were also studied in cats.
Main Results:
- A P1-like potential was identified in and around the PPN of decerebrate rats and cats.
- Thresholds for these potentials were similar to intact preparations, but following frequencies were higher in decerebrate preparations.
- Depth-recorded somatosensory-evoked potentials in cats showed evoked potentials at a similar latency to auditory AEPs.
Conclusions:
- Click stimulus-evoked, depth-recorded potentials are present in and around the PPN in decerebrate rat and cat models.
- These potentials occur in the absence of cortical influence and at latencies comparable to intact preparations.