Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neutrophil functions in essential thrombocythemia

G Carulli1, S Minnucci, A Azzara

  • 1Unit of Hematology, University of Pisa, Italy.

Hematologic Pathology
|January 1, 1995
PubMed
Summary

Essential thrombocythemia (ET) is linked to neutrophil dysfunction. This study found impaired neutrophil function in ET patients, suggesting issues with signal transduction during phagocytosis and f-MLP stimulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benchmarking the Plasmon-Pole and Multipole Approximations in the Yambo Code Using the GW100 Data Set.

Journal of chemical theory and computation·2026
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

Isolated shoulder palsy due to cortical infarction: localisation and electrophysiological correlates of recovery.

BMJ case reports·2025
Same author

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2025
Same author

PREDICTIVE BRCA GENETIC TESTING IN ITALIAN PATIENTS WITH BREAST CANCER: A POSITION PAPER OF ITALIAN SCIENTIFIC SOCIETIES [Italian Association of Medical Oncology(AIOM); Italian Association of Radiotherapy and Clinical Oncology (AIRO); Italian National Association of Breast Surgeons (ANISC); Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP); Italian Society of Surgical Oncology (SICO); Italian Society of Human Genetic (SIGU); Italian Society of General Practice (SIMG); Italian Society of Medical and Interventional Radiology (SIRM)].

Cancer treatment reviews·2025
Same author

First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

Physical review letters·2025

Area of Science:

  • Hematology
  • Immunology
  • Cellular Biology

Background:

  • Chronic myeloproliferative diseases (MPNs) like chronic myeloid leukemia and polycythemia vera are known to involve neutrophil dysfunction.
  • Limited data exists regarding neutrophil function in essential thrombocythemia (ET), another MPN.

Purpose of the Study:

  • To investigate neutrophil function in patients with essential thrombocythemia (ET).
  • To identify specific neutrophil defects associated with ET.

Main Methods:

  • Evaluated 21 ET patients, ensuring adequate washout periods from prior therapies.
  • Assessed neutrophil phagocytosis using flow cytometry with E. coli.
  • Measured whole blood and purified neutrophil chemiluminescence and superoxide anion generation following stimulation with zymosan, f-MLP, and PMA.

Related Experiment Videos

Main Results:

  • Neutrophil chemiluminescence and superoxide anion generation were significantly reduced after f-MLP stimulation compared to controls.
  • Normal neutrophil function was observed after PMA stimulation.
  • Phagocytosis-associated chemiluminescence was impaired, even with normal phagocytic activity, indicating issues beyond initial uptake.

Conclusions:

  • Essential thrombocythemia is associated with complex neutrophil dysfunction.
  • The observed defects may stem from impaired signal transduction pathways during phagocytosis and f-MLP receptor activation in ET patients.