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Published on: October 3, 2018
Waldenström's macroglobulinemia with the AML/MDS-associated t(1;3)(p36;q21)
B Johansson1, J Waldenström, S Hasselblom
1Department of Clinical Genetics, Lund University Hospital, Sweden.
Leukemia
|July 1, 1995
Summary
A rare chromosomal translocation, t(1;3), typically seen in acute myeloid leukemia (AML), was identified in a patient with Waldenström's macroglobulinemia. This finding may explain the patient's aggressive disease progression and bone destruction.
Area of Science:
- Hematology
- Oncology
- Cytogenetics
Background:
- Waldenström's macroglobulinemia (WM) is a lymphoproliferative disorder.
- Chromosomal abnormalities are common in hematologic malignancies and can influence disease course.
Observation:
- A patient with WM presented with unusual bone destruction and hypercalcemia during disease progression.
- The sole clonal chromosomal abnormality identified was a t(1;3)(p36;q21) translocation.
Findings:
- The t(1;3)(p36;q21) translocation is a known characteristic of acute myeloid leukemia (AML) and myelodysplastic syndromes.
- This specific translocation has not been previously reported in any lymphoproliferative disorder, including WM.
Implications:
- The presence of t(1;3) in WM cells suggests a potential role in the neoplastic process and aggressive tumor progression.
- This cytogenetic finding may indicate a myelopoietic lineage involvement or transformation, contributing to the unusual clinical presentation of WM.
