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Comparative study on topical and oral administration of ofloxacin for Pseudomonas corneal ulcer in rabbits
1Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
Abstract:
Pseudomonas aeruginosa is one of the most frequently isolated microorganisms in bacterial corneal ulcers in Japan and other countries. We evaluated a topical application of 0.3% ofloxacin (OFLX) for Pseudomonas corneal ulcer in rabbits and compared it to the clinical effects of OFLX in topical and oral applications. All corneas in the control groups of both experiments showed total leukoma with a score of 4 on the seventh day. On the other hand, in the preventive experiment, all the scores in the OFLX-treated group were 0, and those in the therapeutic experiment were smaller than those of both the control and oral groups. The results indicate that topical OFLX is effective on Pseudomonas corneal ulcer in rabbits.
Insights
Topical ofloxacin (OFLX) effectively treats Pseudomonas corneal ulcers in rabbits. This study shows topical OFLX significantly outperforms control and oral treatments for bacterial keratitis.
Area of Science:
- Ophthalmology
- Microbiology
- Pharmacology
Background:
- Pseudomonas aeruginosa is a leading cause of bacterial keratitis globally.
- Bacterial corneal ulcers pose a significant threat to vision.
Purpose of the Study:
- To evaluate the efficacy of topical 0.3% ofloxacin (OFLX) for Pseudomonas corneal ulcers in a rabbit model.
- To compare topical OFLX with oral OFLX and control treatments.
Main Methods:
- A rabbit model of Pseudomonas aeruginosa corneal ulcer was established.
- OFLX was administered topically and orally, with topical application being the focus.
- Clinical outcomes were assessed using a standardized scoring system.
Main Results:
- Control groups showed severe corneal opacity (score 4) by day seven.
- Preventive topical OFLX treatment resulted in a score of 0.
- Therapeutic topical OFLX showed significantly better outcomes than control and oral OFLX groups.
Conclusions:
- Topical 0.3% ofloxacin is a highly effective treatment for Pseudomonas corneal ulcers in rabbits.
- Topical administration of OFLX demonstrates superior clinical efficacy compared to oral administration for this condition.