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Temporal patterns of stroke onset. The Framingham Study

M Kelly-Hayes1, P A Wolf, C S Kase

  • 1Department of Neurology, Boston University School of Medicine, MA 02118, USA.

Stroke
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

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Stroke incidence shows distinct temporal patterns. Most strokes occur on Mondays, between 8 AM and noon, particularly in winter, suggesting potential preventive strategies. This community-based study offers a clearer view of stroke onset. Keywords: stroke incidence, temporal patterns, preventive strategies.

Area of Science:

  • Epidemiology
  • Neurology
  • Public Health

Background:

  • Previous studies indicated seasonal, weekly, and daily variations in stroke onset, primarily from clinical data susceptible to bias.
  • Understanding these temporal patterns is crucial for insights into stroke pathogenesis.
  • A community-based cohort study is needed to provide a less biased perspective on stroke occurrence.

Purpose of the Study:

  • To investigate the temporal patterns of stroke onset, including month, season, day of the week, time of day, and place of occurrence.
  • To analyze these patterns in relation to stroke incidence, subtype, and gender within a community-based cohort.
  • To identify periods of increased stroke risk for potential preventive strategies.

Main Methods:

  • A 40-year surveillance of the Framingham Study cohort (5070 participants aged 30-62) free of stroke and cardiovascular disease at entry.

Related Experiment Videos

  • Systematic ascertainment of month, season, day of the week, time of day, and place of occurrence for 637 completed initial strokes.
  • Prospective analysis relating temporal factors to stroke incidence, subtype, and gender.

    • Main Results:

    • Winter was the peak season for cerebral embolic strokes.
    • Mondays showed significantly higher stroke event occurrences than other days, especially for working men; intracerebral hemorrhages also peaked on Mondays.
    • Strokes most frequently occurred between 8 AM and noon across all subtypes, even when excluding sleep-related onsets. Hemorrhagic strokes occurred outside the home, and cerebral embolisms occurred more in hospitals.

    Conclusions:

    • The study identified distinct temporal patterns in stroke onset regarding season, day of the week, time of day, and location within a community-based population.
    • These findings highlight specific periods of increased stroke risk.
    • The observed patterns suggest potential opportunities for developing targeted preventive strategies.