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[Albuminuria in persons with real hypertension, white coat hypertension and normotension]

K S Kristensen1, L E Bang, A Høegholm

  • 1Medicinsk afdeling, Centralsygehuset i Naestved.

Ugeskrift for Laeger
|June 5, 1995
PubMed

Insights

White coat hypertension patients show less kidney damage than established hypertensives, but more than normotensive individuals. This study compared blood pressure and urinary albumin levels in different hypertension groups.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • Mild to moderate hypertension requires careful monitoring for early signs of kidney damage.
  • Differentiating between established hypertension and white coat hypertension is crucial for appropriate patient management.
  • Ambulatory blood pressure monitoring and urinary albumin excretion are key indicators of renal involvement.

Purpose of the Study:

  • To compare urinary albumin excretion in patients with established hypertension, white coat hypertension, and normotensive controls.
  • To assess the correlation between blood pressure and early morning urine albumin/creatinine ratio.
  • To evaluate the reproducibility of early morning urine albumin/creatinine ratio compared to 24-hour albumin excretion.

Main Methods:

  • Prospective study of 284 patients with newly diagnosed, untreated hypertension.
  • Classification of hypertension based on office and daytime ambulatory blood pressure measurements.
  • Comparison of urinary albumin/creatinine ratio across established hypertensives, white coat hypertensives, and a normotensive control group.

Main Results:

  • Significant differences in urinary albumin/creatinine ratio were observed between the three groups, even after adjusting for covariables.
  • Early morning urine albumin/creatinine ratio showed a weak but significant correlation with blood pressure.
  • Early morning urine albumin/creatinine ratio demonstrated reproducibility comparable to 24-hour albumin excretion.

Conclusions:

  • White coat hypertensive patients exhibit less renal involvement than established hypertensive patients.
  • Renal involvement in white coat hypertension is greater than in normotensive individuals.
  • Early morning urine albumin/creatinine ratio is a reliable marker for assessing renal involvement in hypertension.

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