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[Cutaneous reactions to gold salts]
V Lizeaux-Parneix1, C Bedane, C Lavignac
1Service de Dermatologie, CHU Dupuytren, Limoges.
Annales De Dermatologie Et De Venereologie
|January 1, 1994
Summary
Skin reactions to gold salts, including lichenoid eruptions and pityriasis rosea, are variable and not specific. Generalized lesions indicate severity and require monitoring.
Area of Science:
- Dermatology
- Rheumatology
- Pharmacology
Context:
- Gold salts (chrysotherapy) are used to treat inflammatory arthropathies.
- Skin reactions are a known adverse effect of gold therapy.
- Differentiating gold-induced reactions from other dermatoses is clinically important.
Purpose:
- To evaluate the clinical features of skin reactions in patients treated with gold salts.
- To determine if observed reactions are specific to gold therapy and can be termed 'gold dermatitis'.
Summary:
- A study of 10 patients treated with Allochrysine for inflammatory arthritis revealed diverse skin reactions, including lichenoid eruptions, pityriasis rosea, eczematoid dermatoses, and urticaria.
- Onset varied from 2 weeks to 8 months.
- Pathology confirmed clinical diagnoses in most cases, with varying degrees of imputability attributed to gold salts.
Impact:
- The observed skin reactions were not specific to gold salts and do not constitute a distinct 'gold dermatitis'.
- Severe lichenoid eruptions and generalized lesions associated with biological signs suggest a marker of severity.
- Findings aid in the accurate diagnosis and management of cutaneous adverse events in patients receiving gold therapy.