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Related Experiment Videos

Peripheral opioid receptors

C Stein1, M Schäfer, A H Hassan

  • 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine and Intramural Research Program, National Institute on Drug Abuse, NIH Baltimore, MD, USA.

Annals of Medicine
|April 1, 1995
PubMed
Summary
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Opioids offer pain relief beyond the brain by acting on peripheral nerves. This research supports developing new opioid analgesics that target the body, not the brain, to avoid side effects.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Immunology

Background:

  • Opioids traditionally target the central nervous system for pain relief.
  • Recent research indicates opioids also act peripherally.
  • Opioid receptors and peptides are found in peripheral nerve endings and immune cells.

Purpose of the Study:

  • To explore the potential of peripherally acting opioids for analgesia.
  • To investigate opioid receptor localization and function outside the central nervous system.
  • To support the development of novel opioid analgesics with reduced central side effects.

Main Methods:

  • Review of experimental and clinical research on peripheral opioid activity.
  • Analysis of studies on opioid receptor localization on sensory nerve terminals.

Related Experiment Videos

  • Examination of opioid peptide presence in immune cells within inflamed tissues.

    • Main Results:

    • Opioids demonstrate potent, receptor-specific analgesic effects peripherally.
    • Opioid receptors are confirmed on peripheral sensory nerve terminals.
    • Endogenous opioid peptides are found in immune cells in inflamed tissues.
    • Clinical studies validate peripheral opioid efficacy.

    Conclusions:

    • Peripheral opioid analgesia is a validated scientific principle.
    • Novel peripherally acting opioid analgesics are a promising therapeutic avenue.
    • These analgesics could offer pain relief with fewer central nervous system side effects.