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Updated: Aug 14, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
J Soulier1, L Grollet, E Oksenhendler
1Laboratoire d'Hématologie Moléculaire, Hôpital Saint-Louis, Paris, France.
Blood
|August 15, 1995
Summary
Human herpesvirus 8 (KSHV) DNA was found in most multicentric Castleman
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder.
- MCD is often associated with Kaposi's sarcoma (KS) and human herpesvirus 8 (KSHV).
Purpose of the Study:
- To investigate the presence of KSHV in MCD patients.
- To determine the role of KSHV in the pathogenesis of MCD, particularly in HIV-infected individuals.
Main Methods:
- KSHV DNA was detected in lymph node and peripheral blood samples from 31 MCD patients.
- Samples were analyzed from both HIV-positive and HIV-negative patients.
- Control lymph node samples from HIV-negative patients were also tested.
Main Results:
- KSHV DNA was detected in all 14 HIV-associated MCD cases, including those without KS.
- KSHV DNA was found in 7 of 17 HIV-negative MCD cases.
- KSHV was detected in only 1 of 34 non-MCD control lymph nodes.
Conclusions:
- KSHV is frequently detected in multicentric Castleman's disease.
- These findings suggest KSHV plays a role in MCD pathogenesis, especially in HIV-infected patients.
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