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Cerebral phaeohyphomycosis complicated with brain abscess: a case report

J F Lirng1, R D Tien, A K Osumi

  • 1Department of Radiology, National Yang-Ming University, Taipei, Taiwan, R.O.C.

Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|June 1, 1995
PubMed

Insights

Cerebral phaeohyphomycosis, a rare brain infection, was treated by surgically removing the abscess and using antifungal drugs. This approach led to a successful recovery for the patient with Xylohypha bantiana infection.

Area of Science:

  • Mycology
  • Neurology
  • Infectious Diseases

Background:

  • Cerebral phaeohyphomycosis is a rare infection of the brain caused by pigmented fungi.
  • It typically manifests as a brain abscess, posing diagnostic and therapeutic challenges.

Observation:

  • A patient presented with seizures, and MRI revealed a ring-enhancing lesion with edema.
  • The lesion, caused by Xylohypha bantiana, recurred after initial surgical removal.

Findings:

  • Diagnosis was confirmed by fungal cultivation and histopathology of Xylohypha bantiana.
  • Combined therapy of surgical excision and antifungal drugs (5-flucytosine, itraconazole) led to a favorable outcome.

Implications:

  • Complete surgical resection of the brain abscess is crucial for managing cerebral phaeohyphomycosis.
  • Aggressive antifungal treatment alongside surgery offers the best prognosis for this rare fungal infection.

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