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New drugs in anesthesia
1Department of Anesthesia, University of California, San Francisco, School of Medicine, Japan, USA.
International Anesthesiology Clinics
|January 1, 1995
Summary
Newer anesthetics like desflurane and sevoflurane offer better control and faster recovery than older agents. While sevoflurane is better for induction and less likely to increase heart rate, both have unique properties and potential drawbacks.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Inhalational anesthetics are crucial for anesthesia delivery.
- Older potent agents have limitations in control and recovery.
- Desflurane and sevoflurane represent advancements in anesthetic agents.
Purpose of the Study:
- To compare the pharmacological properties of desflurane and sevoflurane.
- To evaluate their advantages and disadvantages against older anesthetic agents.
- To assess their potential as ideal anesthetic agents.
Main Methods:
- Comparative analysis of anesthetic agent properties.
- Review of clinical data on desflurane and sevoflurane.
- Pharmacological profiling at various concentrations.
Main Results:
- Desflurane and sevoflurane exhibit lower solubilities, enabling precise anesthetic control and rapid recovery.
- Sevoflurane is non-pungent, suitable for inhalation induction, and less prone to causing tachycardia.
- Desflurane can transiently increase heart rate and blood pressure at higher concentrations.
- Sevoflurane's susceptibility to degradation raises concerns about subtle toxicity.
Conclusions:
- Desflurane and sevoflurane offer significant advantages over older anesthetic agents.
- Each agent possesses unique characteristics, with sevoflurane being preferred for induction.
- Despite limitations, desflurane and sevoflurane represent progress toward ideal anesthetic agents.