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[Two cases with metastatic intracerebral alveolar soft part sarcoma]
1Department of Neurological Surgery, School of Medicine, University of Tokushima, Japan.
No Shinkei Geka. Neurological Surgery
|July 1, 1995
Summary
Alveolar soft part sarcoma (ASPS), a rare tumor, can metastasize to the brain. This report details two cases of intracerebral ASPS, highlighting long-term survival in one patient despite extensive metastasis.
Area of Science:
- Oncology
- Neurosurgery
- Pathology
Background:
- Alveolar soft part sarcoma (ASPS) is a rare soft tissue malignancy.', 'ASPS commonly affects young females, with a predilection for the lower extremities.', 'Metastatic potential is high, with lung, bone, and brain being common sites.'],
Observation:
- Two cases of intracerebral metastatic ASPS originating from primary lower extremity tumors are presented.
- Case 1: A female diagnosed at age 11 with ASPS experienced cerebral metastasis at 37, with long-term survival (44 years from primary onset, 18 years from brain metastasis).
- Case 2: A male diagnosed at age 29 with ASPS developed cerebral metastasis within two years, succumbing to widespread metastasis.
Findings:
- Intracerebral metastasis from primary alveolar soft part sarcoma is a documented occurrence.
- Prognosis for metastatic ASPS to the brain can vary significantly, with potential for long-term survival in select cases.
- Aggressive and widespread metastasis can lead to a rapid fatal outcome.
Implications:
- Highlights the importance of vigilant monitoring for metastatic disease in ASPS patients.
- Suggests that early diagnosis and aggressive management may improve outcomes for select patients with brain metastasis.
- Underscores the aggressive nature of ASPS and the need for further research into targeted therapies.