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Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.3K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.0K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Jan 13, 2026

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
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Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

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[Skin, a privileged target for gene therapy]

V Descamps

    Presse Medicale (Paris, France : 1983)
    |May 27, 1995
    PubMed
    Summary

    Gene therapy offers two skin approaches: direct in vivo or in vitro transfer of genes into skin cells. Cultured skin cells, like keratinocytes, show promise for producing therapeutic proteins for various conditions.

    Area of Science:

    • Dermatology
    • Molecular Biology
    • Gene Therapy

    Background:

    • Gene therapy targets skin cells (keratinocytes, fibroblasts, tumor cells) via direct in vivo or ex vivo (in vitro) methods.
    • In vivo gene transfer requires precise targeting to skin cells, avoiding systemic spread.
    • In vitro methods involve culturing harvested skin cells for therapeutic applications, similar to established skin grafting.

    Discussion:

    • Viral vectors (retroviruses, adenoviruses) and physicochemical methods are explored for gene delivery.
    • Gene therapy holds potential for genodermatoses, localized/systemic therapeutic factor expression, and engineered skin cancer cells.
    • Challenges include efficient and safe gene transfer to specific skin cell populations.

    Key Insights:

    • Cultured keratinocytes and fibroblasts are promising for producing therapeutic proteins with local or systemic effects.

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  • Gene therapy can address genetic skin disorders and enhance cancer treatment.
  • Developing safe and effective gene delivery systems is crucial for clinical translation.

    • Outlook:

    • The most immediate advancements in skin gene therapy are expected from using keratinocytes and fibroblasts for protein production.
    • Further research into non-viral vectors and improved in vivo targeting will enhance therapeutic efficacy.
    • Gene therapy integration into standard dermatological practice is anticipated for treating a range of skin conditions.