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[Is atopy a risk factor of occupational asthma?]
C Lemière1, D Charpin, D Vervloet
1Service de Pneumo-allergologie, Hôpital Sainte-Marguerite, Marseille.
Revue Des Maladies Respiratoires
|January 1, 1995
Summary
Atopy is linked to occupational asthma from high molecular weight allergens, but the connection is less clear for low molecular weight allergens. Excluding individuals with atopy from certain jobs may be excessive.
Area of Science:
- Occupational Health
- Allergology
- Immunology
Context:
- Occupational asthma is classified by allergen molecular weight (high vs. low).
- Atopy is considered a risk factor for high molecular weight allergens but not low molecular weight ones.
Purpose:
- To critically analyze the relationship between atopy and occupational asthma.
- To evaluate the role of atopy in sensitization and asthma development for different allergen types.
Summary:
- A strong link exists between atopy and sensitization to high molecular weight allergens (e.g., snow crabs, flour).
- The relationship between atopy and asthma is debated for high molecular weight allergens, except for baker's asthma.
- Atopy generally does not predispose individuals to asthma from low molecular weight allergens (e.g., isocyanates), though red cedar is an exception.
Impact:
- The distinction between high and low molecular weight allergens regarding atopy's role is less definitive than previously thought.
- Current findings suggest that excluding individuals with atopy from employment may be overly cautious.
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