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Related Experiment Videos

Inhaled frusemide and exercise-induced bronchoconstriction in children with asthma

P Munyard1, K F Chung, A Bush

  • 1Department of Paediatrics, National Heart and Lung Institute, London, UK.

Thorax
|June 1, 1995
PubMed
Summary

Inhaled frusemide effectively reduces exercise-induced bronchoconstriction in children with asthma. This study demonstrates its protective effect, improving lung function after physical exertion.

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Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Pharmacology

Background:

  • Nebulized frusemide offers protection against bronchoconstriction in adults with asthma and cold air challenges in children.
  • Animal studies indicate potential enhanced efficacy of inhaled frusemide in younger individuals.

Purpose of the Study:

  • To evaluate the efficacy of inhaled frusemide in preventing exercise-induced bronchoconstriction in pediatric asthma patients.
  • To assess the impact of pretreatment with frusemide on lung function following standardized exercise challenge.

Main Methods:

  • A double-blind, placebo-controlled, crossover study was conducted.
  • Twelve children with asthma received either frusemide (20 mg via MDI and Volumatic spacer) or placebo before an 8-minute treadmill exercise test.

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  • Lung function, specifically forced expiratory volume in one second (FEV1), was measured post-exercise.

    • Main Results:

    • Children experienced significantly less lung function deterioration after exercise when pretreated with inhaled frusemide compared to placebo.
    • The mean maximum percentage fall in FEV1 was 5.7% with frusemide versus 14.4% with placebo.
    • This indicates a substantial reduction in exercise-induced bronchoconstriction.

    Conclusions:

    • Inhaled frusemide administered via a metered dose inhaler and spacer is effective in reducing exercise-induced bronchoconstriction in children.
    • This finding supports the use of inhaled frusemide as a potential therapeutic strategy for managing exercise-induced asthma in pediatric populations.