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Updated: Aug 8, 2026

14:04
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia
B I Dalal1, P A Keown, F Paraskevas
1Division of Hematopathology, Vancouver General Hospital, BC, Canada.
American Journal of Hematology
|August 1, 1995
Abstract:
We report a patient with acute large granular lymphocyte (LGL) leukemia, presenting as acute myelofibrosis (AMF). The leukemic cells were immature T-cells (CD5+, CD7+, CD16-, CD56-, CD57-, and CD41-), had monosomy 7, and secreted large amounts of Transforming Growth Factor-beta 1(TGF-beta 1). The serum levels of interleukins (IL)-2, -2R, -6 and -8 were elevated, while the IL-1 beta, IL-4, and tumor necrosis factor-alpha were normal.

