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Melkersson-Rosenthal syndrome

M S Daoud1, R S Rogers

  • 1Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.

Seminars in Dermatology
|June 1, 1995
PubMed
Summary

Melkersson-Rosenthal syndrome presents with orofacial swelling, facial paralysis, and fissured tongue, though complete triads are rare. Diagnosis involves identifying sarcoid-like granulomas, and treatment with corticosteroids may offer some benefit for this chronic condition.

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Area of Science:

  • Neurology
  • Dermatology
  • Ophthalmology

Background:

  • Melkersson-Rosenthal syndrome (MRS) is a rare neurological disorder.
  • It is characterized by a triad of recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue.
  • However, the classic triad is infrequently observed in its entirety, with monosymptomatic and oligosymptomatic presentations being more prevalent.

Purpose of the Study:

  • To summarize the key features of Melkersson-Rosenthal syndrome.
  • To highlight diagnostic criteria and common clinical presentations.
  • To discuss current therapeutic approaches for MRS.

Main Methods:

  • Review of existing literature on Melkersson-Rosenthal syndrome.
  • Analysis of diagnostic histological findings, specifically sarcoid-like granulomas.
  • Evaluation of treatment outcomes for corticosteroid therapies.

Main Results:

  • Melkersson-Rosenthal syndrome often presents with incomplete symptom sets.
  • Histopathological examination revealing sarcoid-like granulomas in biopsies is crucial for diagnosis.
  • The syndrome follows a chronic, albeit benign, course.

Conclusions:

  • Accurate diagnosis of Melkersson-Rosenthal syndrome relies on recognizing varied clinical presentations and confirming histological findings.
  • While challenging, treatment strategies involving intralesional or systemic corticosteroids can be beneficial.
  • Further research into effective management of this rare condition is warranted.

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