Ischaemia-reperfusion injury--a small animal perspective

Disease processes that produce ischaemia are a common cause of morbidity and mortality in companion animals. The majority of damage to transiently ischaemia tissues occurs following reperfusion and not during ischaemia per se. This discovery raises the encouraging prospect that therapeutic intervention prior to reperfusion may reduce the severity of ischaemic damage. Recently, the central role of oxygen-derived free radicals (oxyradicals) in reperfusion injury has been demonstrated. It appears that the adverse consequences of ischaemic diseases can be reduced by optimizing the anti-oxidant capability of tissues with anti-oxidant nutrients or drugs. The importance of oxyradicals in individual ischaemic diseases of the dog and cat, however, remains largely uninvestigated. Similarly, the best pharmaceutical and nutritional approaches to the therapy of oxyradical-mediated damage have yet to be devised.