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Pre-eclampsia and trisomy 13

R Heydanus1, P Defoort, M Dhont

  • 1Department of Obstetrics and Gynaecology, University Hospital Ghent, Belgium.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|June 1, 1995
PubMed
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Pre-eclampsia in a 41-year-old woman was linked to trisomy 13. This chromosomal anomaly should be considered when pre-eclampsia occurs with abnormal fetal development.

Area of Science:

  • Maternal-fetal medicine
  • Clinical genetics
  • Obstetrics

Background:

  • Pre-eclampsia is a common pregnancy complication.
  • Severe intrauterine growth restriction (IUGR) and congenital anomalies can indicate underlying fetal chromosomal abnormalities.
  • Trisomy 13 is a severe genetic disorder.

Purpose of the Study:

  • To report a case of pre-eclampsia associated with trisomy 13.
  • To highlight the importance of considering chromosomal abnormalities in specific obstetric scenarios.

Main Methods:

  • Case report of a 41-year-old multiparous woman.
  • Ultrasonic examination for fetal assessment.
  • Amniocentesis for genetic confirmation.

Main Results:

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  • Ultrasonography revealed severe intrauterine growth restriction (IUGR) and multiple congenital anomalies.
  • Amniocentesis confirmed trisomy 13.
  • The patient presented with pre-eclampsia.

Conclusions:

  • Trisomy 13 should be suspected in pregnancies with pre-eclampsia and abnormal fetal morphology.
  • Early suspicion and diagnosis of chromosomal anomalies are crucial for appropriate management.