Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-induced lupus

E J Price1, P J Venables

  • 1Kennedy Institute of Rheumatology, Hammersmith, London, England.

Drug Safety
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Drug-induced lupus, a syndrome mimicking systemic lupus erythematosus, can arise from various medications. Recognizing this condition is crucial as symptoms typically resolve after discontinuing the offending drug.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.

Nature communications·2018
Same author

Cardiovascular risk factors in women with primary Sjögren's syndrome: United Kingdom primary Sjögren's syndrome registry results.

Arthritis care & research·2014
Same author

Sinonasal sarcoid.

Journal of postgraduate medicine·2009
Same author

Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles.

Annals of the rheumatic diseases·2008
Same author

Is Sjogren myelopathy Devic disease?

Annals of the rheumatic diseases·2008
Same author

Management of patients presenting with Sjogren's syndrome.

Best practice & research. Clinical rheumatology·2006
Same journal

Availability and Communication of Risk Management Strategies for Pregnancy Category X Medicines across Australian Medicine Information Sources.

Drug safety·2026
Same journal

The Bidirectionality of Lawyer Reporting Bias in Disproportionality Analysis.

Drug safety·2026
Same journal

Safety of Biologic and Targeted Synthetic Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis: A Longitudinal Analysis.

Drug safety·2026
Same journal

Developing a Hierarchical Algorithm to Identify Pregnancies and Determine Gestational Age from Nationwide Linked Health Data in Taiwan.

Drug safety·2026
Same journal

Safety and Effectiveness of Direct Oral Anticoagulants Versus Low-Molecular-Weight Heparin for Cancer-Associated Thrombosis: A Systematic Review and Meta-analysis.

Drug safety·2026
Same journal

Analytic Misjudgment of Drug Safety Evidence and Causality: From the Prosecutor's Fallacy and Simpson's Paradox to Artificial Intelligence.

Drug safety·2026
See all related articles

Area of Science:

  • Immunology
  • Pharmacology
  • Rheumatology

Background:

  • Drug-induced lupus erythematosus (DILE) is a condition that mimics systemic lupus erythematosus (SLE).
  • It is often associated with specific medications, including procainamide, hydralazine, and certain biological agents.
  • DILE presents with symptoms like arthralgia, myalgia, rashes, and fever, accompanied by antinuclear antibodies.

Purpose of the Study:

  • To review the characteristics, associated drugs, and potential pathogenesis of drug-induced lupus.
  • To highlight the importance of recognizing DILE for prompt management.
  • To explore how studying DILE might offer insights into idiopathic SLE.

Main Methods:

  • Literature review of drug-induced lupus erythematosus.
  • Analysis of common and less frequent causative agents.

Related Experiment Videos

  • Discussion of proposed pathogenetic mechanisms.

    • Main Results:

    • Procainamide and hydralazine are the most common culprits; other drugs and drug classes, including biological agents, are also implicated.
    • DILE typically presents with milder symptoms than idiopathic SLE, with severe manifestations like nephritis being rare.
    • Proposed pathogenesis involves drug-DNA/histone interactions or cytokine network disruption for biological agents.

    Conclusions:

    • Drug-induced lupus is an important, albeit rare, consideration in patients presenting with lupus-like symptoms.
    • Prompt recognition and cessation of the causative agent lead to symptom resolution.
    • Understanding DILE pathogenesis may illuminate mechanisms underlying idiopathic SLE.