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Myosin structure/function: a combined mutagenesis-crystallography approach
K M Ruppel1, M Lorenz, J A Spudich
1Department of Biochemistry and Developmental Biology, Stanford University School of Medicine, CA 94305, USA.
Current Opinion in Structural Biology
|April 1, 1995
Abstract:
In the past year, the structure of the regulatory domain of scallop myosin has joined that of the chicken skeletal muscle myosin subfragment 1 and provided insights into the regulation of myosin function. Mutagenesis studies in a variety of systems have used the information provided by these structures to create mutant myosins to test models of chemomechanical transduction and its regulation.