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Updated: Sep 15, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
Myocardial ischemia induced by topical use of 5-fluorouracil
Y Rozenman1, J Gurewich, M S Gotsman
1Department of Cardiology, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.
Abstract:
An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead. Half an hour after application the patient developed her typical ischemic pain which persisted for 2 hours. Rechallenge, during hospitalization, resulted in recurrence of symptoms that were effectively controlled with sublingual isosorbide dinitrate. Prophylactic therapy with nitroglycerin patch enabled further use of the 5-fluorouracil cream for the next month.
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