Chemical modification of tylosin
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1Institut de Chimie des Substances Naturelles du C.N.R.S., Gif sur Yvette, France.
The Journal of Antibiotics
|July 1, 1995
Abstract:
20-Homo tylosin, 20-nor tylosin, 20-deoxy-19,20-didehydro tylosin (6-vinyl tylosin) and 2",3"-didehydro-3"-deoxy tylosin were prepared by multi-step procedures. 20-Homo tylosin was about twice less active than tylosin while the other compounds exhibited very weak antibacterial activity.