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2,3-Butanedione monoxime (BDM) increases initial yields and improves long-term survival of isolated cardiac myocytes
T Kivistö1, M Mäkiranta, E L Oikarinen
1Department of Physical Sciences, University of Oulu, Finland.
The Japanese Journal of Physiology
|January 1, 1995
Abstract:
When BDM is added to the perfusion solutions used during the preparation of single, enzymatically dispersed mammalian cardiomyocytes, higher yields of calcium-tolerant cells are obtained. As the principal component of a storage solution, BDM also improves the survival of myocytes maintained in cold storage. These data support the hypothesis that BDM can act as a cardioprotective agent under certain conditions.