Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of T-lymphocyte proliferation in exercise-induced asthma

T B Bury1, J L Corhay, R Louis

  • 1Department of Respiratory Medicine, CHU Sart Tilman, University of Liège, Belgium.

Allergy
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Forced oscillation technique in progressive pulmonary fibrosis in a single-center retrospective study.

Scientific reports·2025
Same author

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.

Journal of investigational allergology & clinical immunology·2025
Same author

Increase in Blood Eosinophil Count Over Time and Sputum IL8 are Associated with FEV<sub>1</sub> Decline in Asthma.

Lung·2024
Same author

Biologics for eosinophilic otitis media: a retrospective case study in a multidisciplinary center.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2024
Same author

[Probe based confocal laser endomicroscopy in thoracic endoscopy].

Revue des maladies respiratoires·2023
Same author

Back to the roots of medicine: It's severe asthma patient-reported symptoms that matter!

Pulmonology·2023
Same journal

Route of Allergen Immunotherapy: A Global Look Into Physicians' Motivations.

Allergy·2026
Same journal

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy.

Allergy·2026
Same journal

Decoding the "Metallic" Immune Imprint: Single-Cell Exposomics Reveals the Immune Imprint of Fire Smoke.

Allergy·2026
Same journal

Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children-An EAACI Scoping Review.

Allergy·2026
Same journal

Detergent-Containing Toothpaste Decreases Esophageal Mucosal Impedance and Alters Salivary Properties in Humans.

Allergy·2026
Same journal

Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals.

Allergy·2026
See all related articles

Physical exercise temporarily increases plasma histamine in exercise-induced asthma (EIA) patients, followed by a significant decrease in T-lymphocyte proliferation. This suggests a link between histamine release and immune function changes in EIA.

Area of Science:

  • Immunology
  • Exercise Physiology
  • Respiratory Medicine

Background:

  • Exercise can impact immune function.
  • Asthma patients, particularly those with exercise-induced asthma (EIA), may experience altered immune responses post-exercise.

Purpose of the Study:

  • To investigate the effect of physical exercise on T-lymphocyte proliferation in patients with exercise-induced asthma (EIA).
  • To explore the relationship between plasma histamine levels and T-lymphocyte function following exercise in EIA patients.

Main Methods:

  • Submaximal exercise testing on a treadmill.
  • Measurement of ventilatory variables, plasma histamine, and T-lymphocyte proliferation (spontaneous and PHA-pulsed) before and after exercise.
  • Isolation of mononuclear cells using Ficoll-Hypaque and assessment of tritiated thymidine incorporation.

Related Experiment Videos

Main Results:

  • Asthmatic subjects with EIA showed a significant decrease in FEV1 post-exercise.
  • Plasma histamine levels significantly increased 10 minutes after exercise in EIA patients, returning to normal within 20 minutes.
  • T-lymphocyte proliferation significantly decreased 2 and 4 hours post-exercise in EIA patients, with no changes observed in normal subjects.

Conclusions:

  • Exercise induces a rapid, transient increase in plasma histamine in EIA patients.
  • This histamine surge is followed by a significant reduction in T-lymphocyte proliferation.
  • A potential link exists between exercise-induced histamine release and suppressed T-lymphocyte function in EIA.