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Intravenous regional anesthesia with meperidine
1University of Medicine and Pharmacy, Department of Anaesthesia and Intensive Care, Clinical Hospital, Cluj-Napoca, Romania.
Anesthesia and Analgesia
|September 1, 1995
Summary
Meperidine demonstrated local anesthetic properties in intravenous regional anesthesia (IVRA), with faster onset but slower recovery than lidocaine. Its use for IVRA is a secondary option due to increased side effects compared to lidocaine.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Intravenous regional anesthesia (IVRA) is a technique for limb surgery.
- Assessing alternative agents for IVRA is crucial for patient safety and efficacy.
Purpose of the Study:
- To evaluate the efficacy and safety of meperidine as a local anesthetic in IVRA.
- To compare meperidine with lidocaine and saline for IVRA of the upper limb.
Main Methods:
- A double-blind, randomized study involving 45 volunteers divided into three groups.
- Groups received IVRA with meperidine, lidocaine, or sodium chloride.
- Onset and recovery of sensory and motor blocks were assessed, along with adverse effects.
Main Results:
- Meperidine showed a faster onset of sensory block than saline but slower than lidocaine.
- Complete motor block was achieved in all meperidine and lidocaine groups, but less so in the saline group.
- Meperidine group experienced higher incidence of dizziness, nausea, and injection site pain.
Conclusions:
- Meperidine exhibits local anesthetic effects on peripheral nerves in vivo.
- Meperidine is a potential alternative for IVRA, particularly for patients with local anesthetic allergies.
- Lidocaine remains a preferred agent due to a better side effect profile.