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Prospective randomised comparative study of pulse spray and conventional local thrombolysis
S W Yusuf1, S C Whitaker, R H Gregson
1Department of Vascular Surgery, University Hospital, Nottingham, U.K.
Summary
The pulse spray technique significantly reduces thrombolytic therapy time compared to conventional infusion. This faster method achieves lysis more efficiently for intra-arterial thrombolysis.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Thrombolytic Therapy
Background:
- Intra-arterial thrombolysis is crucial for treating vascular occlusions.
- Conventional slow continuous infusion of thrombolytics can be time-consuming.
- Optimizing thrombolytic delivery methods is essential for patient outcomes.
Purpose of the Study:
- To compare the efficacy of pulse spray technique versus conventional slow continuous infusion for thrombolysis.
- To determine the time required to achieve lysis using both methods.
Main Methods:
- A prospective randomized open study involving 18 patients.
- Patients received either pulse spray thrombolysis (0.33 mg/ml rt-PA bolus) or conventional thrombolysis (0.05 mg/ml rt-PA infusion).
- Randomization was 1:1 between the two treatment groups.
Main Results:
- The median duration of thrombolytic therapy was significantly shorter in the pulse spray group (195 min) compared to the conventional group (1390 min).
- The difference in treatment duration was statistically significant (p < 0.002).
- Patient demographics and occlusion characteristics were comparable between groups.
Conclusions:
- The pulse spray technique offers a significantly faster method for achieving local thrombolysis.
- This technique represents a more time-efficient approach compared to conventional infusion methods.
- Pulse spray technique may improve efficiency in intra-arterial thrombolytic therapy.