Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Measuring technetium-99m-MAG3 clearance with an improved camera-based method

A Taylor1, P L Corrigan, J Galt

  • 1Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of topical flurbiprofen on trabeculectomy.

Journal of glaucoma·2009
Same author

Smooth estimation of the reliability function.

Lifetime data analysis·2002
Same author

Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings.

The American journal of psychiatry·2001
Same author

Risk factors for premature ovarian failure in females with galactosemia.

The Journal of pediatrics·2000
Same author

Platelet reactivity in depressed patients treated with paroxetine: preliminary findings.

Archives of general psychiatry·2000
Same author

Multicenter trial validation of a camera-based method to measure Tc-99m mercaptoacetyltriglycine, or Tc-99m MAG3, clearance.

Radiology·1997
Same journal

SSTR-Targeted Radiotheranostics in Breast Cancer: A Comparison of [<sup>68</sup>Ga]Ga-DOTATOC and [<sup>68</sup>Ga]Ga-SSO120 with [<sup>18</sup>F]FDG PET.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

Prognostic Value of Restaging [<sup>18</sup>F]FDG PET/CT in Patients with Metastatic Castration-Resistant Prostate Cancer Undergoing [<sup>177</sup>Lu]Lu-PSMA-617 Therapy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

Radiation-Induced Senescence in Radiopharmaceutical Therapy: Mechanisms and Therapeutic Implications.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

Discovery of a Thermostable Nigerose Phosphorylase for the Efficient Chemoenzymatic Radiosynthesis of a <i>S. aureus</i>-Targeted <sup>18</sup>F-Disaccharide.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

End-to-End PET/CT Interpretation and Quantification with an LLM-Orchestrated AI Agent: A Real-World Pilot Study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same journal

Renal Medullary Carcinoma: Utility of [<sup>18</sup>F]FDG PET/CT in Evaluating Extent of Disease and Impact on Treatment Management.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
See all related articles

This study presents an optimized camera-based method for calculating renal clearance using technetium-99m-mercaptoacetyltriglycine (99mTc-MAG3). The new technique improves precision by accounting for dose infiltration and timing discrepancies, enhancing diagnostic accuracy in renal function assessment.

Area of Science:

  • Nuclear Medicine
  • Renal Physiology
  • Medical Imaging

Background:

  • Commercially available camera-based methods for renal clearance lack optimization.
  • Existing methods fail to account for critical factors like dose infiltration, table attenuation, and injection-to-camera timing discrepancies.

Purpose of the Study:

  • To develop and validate an optimized camera-based clearance method for 99mTc-MAG3.
  • To improve the precision and accuracy of renal function assessment using nuclear imaging.

Main Methods:

  • Technetium-99m-MAG3 scintigraphy performed in 20 patients with varying renal function.
  • Acquisition of posterior data with specific frame rates and automated background correction.
  • Estimation of renal depth, correction for table attenuation, and timing discrepancies; correlation of percent injected dose with MAG3 clearance.

Related Experiment Videos

Main Results:

  • High correlation observed between percent injected dose in the kidney and multisample clearance.
  • Body surface area correction significantly improved correlation coefficients.
  • Development of regression equations to predict multisample clearance based on percent dose and body surface area.

Conclusions:

  • The optimized camera-based method enhances precision for sequential renal studies.
  • The developed technique offers a more accurate assessment of renal function using 99mTc-MAG3 scintigraphy.