Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The IL-2 receptor complex: expression and function on normal and leukemic B cells

D de Totero1, P Francia di Celle, A Cignetti

  • 1Istituto Nazionale per la Ricerca sul Cancro, Laboratorio di Patologia Clinica, Genova, Italy.

Leukemia
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcome of Adult Lymphoblastic Lymphoma Patients Treated in the Real Life According to the Gimema LAL1913 Protocol: A Campus ALL Multicenter Study.

Hematological oncology·2025
Same author

A venetoclax and azacitidine bridge-to-transplant strategy for NPM1-mutated acute myeloid leukaemia in molecular failure.

British journal of haematology·2023
Same author

Treatment discontinuation following low-dose TKIs in 248 chronic myeloid leukemia patients: Updated results from a campus CML real-life study.

Frontiers in pharmacology·2023
Same author

Phototherapy and topical treatments for cutaneous graft vs. host disease in haematopoietic stem cell transplantation patients: a scoping review.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA Interdisciplinary Expert Consensus.

ESMO open·2022
Same author

A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia.

Case reports in hematology·2020

This review explores the interleukin 2 receptor (IL-2R) complex, focusing on its expression and function in normal and leukemic B cells. Understanding IL-2R interactions is crucial for leukemia research and potential therapeutic strategies.

Area of Science:

  • Immunology
  • Hematology
  • Molecular Biology

Background:

  • The interleukin 2 receptor (IL-2R) comprises multiple protein chains (alpha, beta, gamma).
  • IL-2R alpha chain expression is documented on various human leukemic cells.
  • Limited information exists regarding the beta and gamma chains' roles in leukemias.

Purpose of the Study:

  • To review the expression and function of the IL-2R complex on normal and leukemic human B cells.
  • To discuss the potential role of IL-2-IL-2R interactions in leukemia pathogenesis.
  • To explore implications for neoplastic clone expansion and clinical disease progression.

Main Methods:

  • Literature review focusing on IL-2R expression and function.
  • Analysis of studies concerning IL-2R subunits (alpha, beta, gamma) in B cell malignancies.

Related Experiment Videos

  • Synthesis of current knowledge on IL-2 signaling in leukemia.

    • Main Results:

    • IL-2R subunits show variable expression patterns on normal and neoplastic lymphocytes.
    • IL-2-IL-2R interactions are implicated in the biology of various leukemias.
    • Specific roles of IL-2R beta and gamma chains in B cell leukemias require further elucidation.

    Conclusions:

    • The IL-2R complex plays a significant role in normal and leukemic B cell biology.
    • Understanding IL-2R function may offer insights into leukemia development and progression.
    • Targeting IL-2R pathways could represent a future therapeutic avenue for B cell leukemias.