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The IL-2 receptor complex: expression and function on normal and leukemic B cells

D de Totero1, P Francia di Celle, A Cignetti

  • 1Istituto Nazionale per la Ricerca sul Cancro, Laboratorio di Patologia Clinica, Genova, Italy.

Leukemia
|September 1, 1995
PubMed

The interleukin 2 receptor (IL-2R) is composed of at least three different chains that may be variably expressed on normal and neoplastic lymphocytes. While considerable knowledge has been gained on the expression of the IL-2R alpha chain on human leukemic cells of different origin, less is known of the beta and gamma chains. In view of the highly pleiotropic functions exerted by IL-2, the IL-2-IL-2R interactions may play an important role in various leukemias. In this review we focus on the expression and function of the IL-2R complex on human normal and leukemic B cells. Possible implications in the expansion of the neoplastic clone and in the clinical course of the disease are discussed.

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