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Platelet function analysis after in vitro treatment with hemostasis-affecting components

I Tigchelaar1, S H Monnink, J Haan

  • 1Department of Blood Interaction Research, Cardiothoracic Surgery, University of Groningen, The Netherlands.

Seminars in Thrombosis and Hemostasis
|January 1, 1995
PubMed
Summary
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Platelet function analysis effectively screens materials and plasma substitutes for blood compatibility. This method assesses hemostatic function, identifying materials that may impair blood clotting and evaluating local hemostatic agents for bleeding control.

Area of Science:

  • Biomaterials Science
  • Hematology
  • Medical Device Testing

Background:

  • Assessing the hemostatic function of blood interacting with materials is crucial for biocompatibility testing.
  • Platelet function tests under arterial pressure conditions simulate physiological environments.

Purpose of the Study:

  • To evaluate the utility of platelet function analysis in screening materials and plasma substitutes for blood compatibility.
  • To assess the efficacy of local hemostatic agents in controlling bleeding.

Main Methods:

  • Whole blood platelet function analysis (Thrombostat) was performed on blood from healthy volunteers after incubation with materials or plasma substitutes.
  • Biocompatibility was assessed by observing the impact on platelet plug formation and thrombin binding.

Related Experiment Videos

  • The capacity of local hemostatic agents to enhance platelet plug formation was tested directly on the Thrombostat measuring cell.

    • Main Results:

    • Biocompatibility tests effectively distinguished between compatible and non-compatible materials.
    • Non-compatible materials significantly reduced hemostatic capacity after one-hour incubation, evidenced by increased thrombin binding.
    • Plasma substitutes showed no significant impact on hemostasis.
    • A 40% blood dilution, mimicking cardiopulmonary bypass, exponentially increased platelet plug formation time.
    • Local hemostatic agents, particularly when combined with ADP, demonstrated enhanced platelet plug formation capacity.

    Conclusions:

    • Platelet function analysis is a valuable tool for screening materials and plasma substitutes for their interaction with primary hemostasis.
    • The method can guide the selection of effective local hemostatic agents for bleeding control.