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Analysis of Usnea fasciata crude extracts with antineoplastic activity
E C Periera1, S C Nascimento, R C Lima
1Department of Plant Physiology, Faculty of Biology, Complutense University, Spain.
The Tokai Journal of Experimental and Clinical Medicine
|September 1, 1994
Abstract:
Different fractions, isolated from the lichen Usnea fasciata, were analyzed by PC, TLC, and RP-HPLC. Analysis of the organic phases, mainly containing phenolics, revealed that usnic acid is the main product from secondary metabolites, whereas the polysaccharides isolichenin and raffinose are the most abundant water-soluble carbohydrates. Fractions containing usnic acid, as well as those containing isolichenin, showed moderate activity against sarcoma 180 and Ehrlich tumor cells. High antitumoral activity, near 90% inhibition, was found associated with the fraction containing raffinose.