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Cardioprotective drugs decrease the Na+ background current

S R Park1, G H Ryu, C K Suh

  • 1Department of Physiology, Inha University College of Medicine, Inchon, Korea.

Yonsei Medical Journal
|July 1, 1995
PubMed
Summary
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The Na+ background current contributes to intracellular sodium accumulation during cardiac arrest. Cardioprotective drugs like R 56865 block this current, potentially protecting the heart.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Pharmacology

Background:

  • Intracellular calcium overload is a key factor in cardiac dysfunctions like myocardial failure and ventricular arrhythmia.
  • Sodium-calcium exchange during reperfusion, driven by intracellular sodium accumulation, contributes to calcium overload.
  • Potential sources of intracellular sodium accumulation include Na+ channels, Na(+)-H+ exchange, Na(+)-Ca2+ exchange, and the Na+ background current.

Purpose of the Study:

  • To investigate the role of the Na+ background current in intracellular sodium accumulation during cardiac arrest.
  • To evaluate the effects of cardioprotective drugs on the Na+ background current in guinea pig ventricular myocytes.

Main Methods:

  • Whole-cell patch clamp technique was used to measure Na+ background current in guinea pig ventricular myocytes.

Related Experiment Videos

  • Experiments were conducted in both Ca2+-free and Ca2+-containing solutions.
  • The effects of verapamil, O-(N, N-hexamethylene)-amiloride (HMA), and the drug R 56865 on the Na+ background current were assessed.

    • Main Results:

    • The Na+ background inward current was larger in Ca2+-free solution compared to 1.8 mM Ca2+ solution at -40 mV.
    • Verapamil did not affect the Na+ background current.
    • O-(N, N-hexamethylene)-amiloride (HMA) reduced the Na+ background current at negative membrane potentials.
    • The cardioprotective drug R 56865 decreased the Na+ background current.

    Conclusions:

    • The Na+ background current plays a role in elevating intracellular sodium activity during high K+ cardioplegia.
    • Myoprotective drugs, exemplified by R 56865, may exert their beneficial effects by blocking the Na+ background current, contributing to myocardial protection post-cardioplegia.