[Pharmacokinetics of zinc acexamate (ZAC) in rats]

Zinc acexamate (ZAC) is a new antiulcer drug. This paper reports the pharmacokinetics of ZAC in rats after single oral administration. The concentrations in biological samples were detected by spectrophotometry. This study shows that the concentration-time curve of ZAC in blood conformed to a single-compartment open model after 250, 500 and 750 ng.kg-1 ig. ZAC absorption was fast and the peak plasma level appeared in 1.5 h. The Cmax, AUC and CL/F were shown to be dose dependent. Two hours after oral administration of ZAC to normal rats, the highest level of ZAC was present in the gastrointestinal tract, while appreciable ZAC was present in the kidney, liver, plasma and lung. The level of ZAC in heart, spleen and brain was lower, no drug was detected in muscles and uterus. Six hours after oral administration, the drug concentration in various tissues decreased rapidly, but that of the gastrointestinal decreased very slowly. Feces excretion was an important route of excretion. ZAC excretion was about 11.7% of the administered dosage in feces within 48 h period, and the excreted amount from urine and bile was very small.