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Related Experiment Videos

[Porfimer sodium (Photofrin-II)]

S Tsukagoshi1

  • 1Cancer Chemotherapy Center, Japanese Fundation for Cancer Research.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 1, 1995
PubMed
Summary

Photodynamic therapy (PDT) using porfimer sodium and laser light effectively treats various early-stage cancers by selectively targeting tumor cells. This innovative cancer treatment shows high complete response rates with manageable side effects.

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Area of Science:

  • Oncology
  • Biochemistry
  • Photomedicine

Context:

  • Photodynamic therapy (PDT) utilizes photosensitizers activated by light to induce tumor cell death.
  • Porfimer sodium (Photofrin II) is a photosensitizer with selective tumor tissue distribution.
  • PDT offers a novel therapeutic approach for cancer treatment.

Purpose:

  • To evaluate the efficacy and safety of porfimer sodium-mediated photodynamic therapy in preclinical and clinical settings.
  • To elucidate the mechanisms of porfimer sodium's tumor selectivity and its therapeutic action.
  • To assess the clinical utility of PDT for early-stage and inoperable cancers.

Summary:

  • Porfimer sodium selectively accumulates in tumor tissues due to its affinity for lipoproteins and enhanced LDL receptor activity in cancer.
  • Laser irradiation (630 nm) activates porfimer sodium, generating singlet oxygen that oxidizes cellular components and destroys tumor capillaries.
  • Experimental models and human clinical trials demonstrated significant tumor growth suppression and high complete response rates for various cancers, including lung, esophageal, and cervical cancers.

Impact:

  • PDT with porfimer sodium demonstrates significant potential for treating inoperable early-stage cancers.
  • This therapy can aid in the conservation of organ function by minimizing damage to surrounding healthy tissues.
  • The observed high complete response rates and manageable side effects suggest PDT's clinical value in oncology.

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