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Eukaryotic DNA replication
1Department of Biochemistry, University of California, San Francisco 94143-0448, USA.
Current Opinion in Cell Biology
|June 1, 1995
Abstract:
Recent discoveries suggest that the initiation of eukaryotic DNA replication involves at least two steps--one occurring near the completion of mitosis and the other at the onset of S phase--that bring about the ordered assembly of initiator proteins at the origin. The identification and characterization of components involved in promoting or antagonizing each of these steps has provided a preliminary understanding of how replication initiation is regulated so precisely during the cell cycle.