[The possible restructuring of myosin bridges on the thick filament surface, caused by muscle activation]

In one of author's previous work the stepping cross-bridge model has been proposed. It was shown that the structure of actin filaments and their arrangement in muscle sarcomere ensure the whole necessary condition for the stepping cross-bridges movement in contracting muscle. In this work the requirements put on the thick filament structure by the stepping cross-bridge model are determined. The consideration leads to the conclusion on the rearrangement of myosin cross-bridges on the thick filament surface caused by the activation of the muscle.