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MHC class I-hormone receptor associations: still a physiological enigma?
G A Cremaschi1, L Sterin-Borda
1Centro de Estudios Farmacológicos y Botánicos (CEFYBO), CONICET, Buenos Aires, Argentina.
Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y [De] La Asociacion Latinoamericana De Farmacologia
|January 1, 1994
Summary
Major Histocompatibility Complex (MHC) class I molecules interact with hormone receptors, influencing cellular functions beyond immunity. This molecular association impacts cellular physiology through non-immunological pathways.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Major Histocompatibility Complex (MHC) class I molecules are crucial for immune response regulation.
- Emerging evidence suggests non-immunological roles for MHC class I molecules.
Purpose of the Study:
- To investigate the molecular association between MHC class I molecules and various hormone receptors.
- To explore the functional consequences of these interactions on cellular physiology.
Main Methods:
- Immunoprecipitation assays
- Binding assays
- Immunofluorescence techniques
Main Results:
- MHC class I molecules associate with multiple hormone receptors, including insulin R, EGF R, IL-2 R, LH-R, beta adrenergic R, and muscarinic cholinergic R.
- Antibodies against MHC class I products can activate beta adrenergic R, muscarinic cholinergic R, and LH-R, leading to second messenger production.
- Peptides derived from MHC class I molecules also activate insulin R.
Conclusions:
- MHC class I molecules engage in non-immunological interactions with hormone receptors, modulating cellular functions.
- The selectivity of receptor involvement is likely linked to the cell's physiological requirements.
- Cytoskeletal proteins and ligand-mediated microaggregation may play roles in mediating these molecular associations and their biological effects.