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Long-circulating liposomes

N Oku1, Y Namba

  • 1Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1994
PubMed
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Liposomes enhance drug delivery and reduce side effects. Modifying liposomes, particularly with glucuronide, helps them avoid the reticuloendothelial system (RES) for improved tumor targeting and longer circulation.

Area of Science:

  • Nanotechnology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Liposomes are investigated as drug carriers, showing enhanced efficacy and reduced side effects.
  • Liposome properties like size and charge influence bloodstream stability, clearance, and biodistribution.
  • Conventional liposomes are trapped by the reticuloendothelial system (RES), limiting non-RES targeting.

Purpose of the Study:

  • To review methods for avoiding RES-trapping and prolonging liposome circulation time.
  • To discuss the mechanism of RES avoidance by liposome modifiers.
  • To highlight the utility of long-circulating liposomes for tumor imaging and therapy.

Main Methods:

  • Review of literature on liposome modification strategies.
  • Analysis of modifiers such as monosialoganglioside GM1, polyethyleneglycol, and glucuronide derivatives.

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  • Focus on the mechanism of RES avoidance induced by these modifiers.

    • Main Results:

    • Liposome modification can prevent RES trapping and extend circulation times.
    • Long-circulating liposomes passively accumulate in tumor tissues due to leaky vasculature.
    • Glucuronide derivatives are highlighted as effective modifiers for RES avoidance.

    Conclusions:

    • Long-circulating liposomes are valuable tools for drug delivery, particularly in oncology.
    • Understanding RES avoidance mechanisms is crucial for optimizing liposome-based therapies.
    • Targeted delivery to tumors is enhanced by liposomes engineered for prolonged circulation.