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Radio-chemotherapeutic treatment of advanced ovarian cancer
1Department of Gynaecologic Oncology and Radiotherapy, Justus-Liebig-University Giessen, Germany.
Background:
The role of irradiation seems to be not very important in the post-operative treatment of cancer of the ovaries compared to chemotherapy although it has proved to be highly effective.
Materials And Methods:
In a retrospective study 37 patients with advanced cancer of the ovaries Stages IIIb and IIIc (FIGO) undergoing post-operative consecutive radio-chemotherapy consisting of two series of whole abdominal radiation (WAR) applied in sandwich technique with 6 courses of cisplatin-epirubicin-cyclophosphamide (PEC) were evaluated. For the effectiveness of WAR and PEC-chemotherapy changes of CA 125 serum levels were noted.
Results:
Both WAR and PEC-chemotherapy proved to be effective in 50.5% of the patients, either WAR and PEC-chemotherapy were effective in 16.2% neither one affected the course of disease in 8.1%. Statistical analysis shows a good correlation between the effectiveness of WAR and survival but no such correlation as to the effectiveness of PEC-chemotherapy.
Conclusion:
The role of irradiation in the treatment of ovarian cancer is underestimated. The addition of WAR at the beginning of the post-operative treatment can prolong the survival time in advanced stages of ovarian cancer.