Related Experiment Video
Updated: Aug 15, 2026
06:25
Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
Published on: February 6, 2012
Agonadal presumptive XX/XY leukochimeric pig
B G Clarkson1, K R Fisher, G D Partlow
1Department of Biomedical Sciences, Ontario Veterinary College University of Guelph, Canada.
The Anatomical Record
|June 1, 1995
Summary
This study details a rare XX/XY chimeric piglet with unpredictable reproductive anatomy. The investigation revealed an intersex condition, highlighting the complex development of reproductive organs in chimeric animals.
Area of Science:
- Reproductive Biology
- Developmental Biology
- Genetics
Background:
- XX/XY chimerism in pigs is rare, presenting variable and unpredictable reproductive anatomy.
- Intersex conditions in livestock can pose challenges for breeding and research.
Purpose of the Study:
- To characterize the reproductive anatomy and hormonal profile of an XX/XY chimeric piglet.
- To investigate the developmental basis of intersexuality in this rare condition.
Main Methods:
- Karyotyping and hormonal analysis (testosterone, estrone sulfate) were performed on blood samples.
- Detailed dissection and histological examination of the reproductive tract were conducted post-euthanasia.
- Phenotypic assessment included monitoring vulva development.
Main Results:
- The piglet was identified as a 70% XX/30% XY chimera.
- The reproductive tract lacked gonads but showed both Wolffian and Müllerian duct derivatives.
- Hormonal analysis revealed negligible levels of testosterone and estrone sulfate.
Conclusions:
- The enlarged vulva and Wolffian duct remnants suggest in utero androgen exposure.
- The presence of Müllerian duct remnants and low sex steroid levels support an atesticular state.
- This case underscores the complex developmental pathways in XX/XY chimeric mammals.
