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Thyroid hormone (fT4) reduces lipoprotein(a) plasma levels
F Hoppichler1, C Sandholzer, R Moncayo
1Department of Internal Medicine, University of Innsbruck, Austria.
Atherosclerosis
|May 1, 1995
Summary
Thyroid hormone influences lipoprotein(a) [Lp(a)] levels. Hyperthyroidism is associated with lower Lp(a) concentrations, which normalize after treatment, correlating with LDL-C changes.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Lipid Metabolism
Background:
- Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerosis.
- Thyroid hormones significantly impact lipid metabolism.
- The relationship between thyroid status and Lp(a) levels requires further elucidation.
Purpose of the Study:
- To investigate the influence of thyroid hormone on Lp(a) plasma concentration.
- To assess changes in Lp(a) and other lipids during treatment of hyperthyroidism.
Main Methods:
- Prospective follow-up study of 26 hyperthyroid patients.
- Measurement of Lp(a), total cholesterol, LDL-C, HDL-C, triglycerides, and free T4.
- Determination of apolipoprotein(a) phenotypes before and after thyreostatic treatment.
Main Results:
- Hyperthyroid patients exhibited significantly reduced pretreatment levels of total cholesterol, LDL-C, and Lp(a) compared to controls.
- During treatment, TC, LDL-C, and HDL-C increased significantly, while mean Lp(a) remained unchanged after 4 weeks.
- Individual changes in Lp(a) correlated significantly with LDL-C changes (R = 0.40, P = 0.04).
Conclusions:
- Lp(a) plasma levels are decreased in the hyperthyroid state.
- Thyroid hormone status influences Lp(a) concentrations.
- Lp(a) levels tend to normalize with normalization of thyroid function, showing a correlation with LDL-C adjustments.