Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Absorption interactions with fluoroquinolones. 1995 update

B M Lomaestro1, G R Bailie

  • 1Albany Medical Center Hospital, Pharmacy Department, New York, USA.

Drug Safety
|May 1, 1995
PubMed
Summary

Fluoroquinolone antibiotic use is growing, but absorption can be significantly reduced by multivalent cations found in antacids and supplements. Careful timing of doses is crucial to maintain antibiotic effectiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population pharmacokinetics of extended-infusion piperacillin-tazobactam in hospitalized patients with nosocomial infections.

Antimicrobial agents and chemotherapy·2012
Same author

Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin.

Antimicrobial agents and chemotherapy·2008
Same author

Erythropoietin effectiveness index : a quantitative definition of resistance in haemodialysis patients with adequate iron stores.

Clinical drug investigation·2008
Same author

Pharmacokinetics of intraperitoneal cefazolin and ceftazidime coadministered to CAPD patients.

The International journal of artificial organs·2005
Same author

Peritonitis in automated peritoneal dialysis: antibiotic therapy and pharmacokinetics.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·2002
Same author

Nutritional markers during peritoneal dialysis: data from the 1998 Peritoneal Dialysis Core Indicators Study.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·2001

Area of Science:

  • Pharmacology
  • Microbiology
  • Drug Interactions

Background:

  • The expanding utility of fluoroquinolone antibiotics necessitates understanding their interactions.
  • Fluoroquinolones are increasingly used for serious infections and as oral step-down therapy.
  • Reduced bioavailability due to drug interactions can compromise treatment efficacy.

Purpose of the Study:

  • To highlight the critical importance of absorptive interactions with fluoroquinolones.
  • To discuss the impact of multivalent cations on fluoroquinolone bioavailability.
  • To review the clinical implications of these interactions.

Main Methods:

  • Literature review of pharmacokinetic interactions involving fluoroquinolones.
  • Analysis of reported chelation interactions with multivalent cations.
  • Evaluation of the impact of common co-administered drugs.

Main Results:

  • Chelation interactions with multivalent cations can inactivate fluoroquinolones, affecting both in vitro and in vivo efficacy.
  • These interactions occur in a significant percentage of patients (22-76%).
  • Magnesium-aluminum antacids, sucralfate, iron, calcium, and zinc demonstrate the most substantial impact on fluoroquinolone bioavailability.

Conclusions:

  • Concurrent administration of certain cations significantly reduces fluoroquinolone absorption.
  • Strategies like dose spacing are proposed but may complicate the administration of cation-containing products.
  • Awareness and management of these interactions are vital for optimizing fluoroquinolone therapy.

Related Experiment Videos