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Selective metabolic activation by apomorphine in striosomes of denervated striatum in MPTP-induced hemiparkinsonian
F E Pontieri1, J J Viola, L Sokoloff
1Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD, USA.
Abstract:
Results of previous studies have suggested differences in the regulatory mechanisms in striatal striosomes and matrix following interruption of dopaminergic input to the striatum by MPTP in the monkey. In the present study we have investigated the possibility that stimulation of dopamine receptors by apomorphine modifies glucose metabolism differentially in the two striatal compartments of unilaterally MPTP-lesioned monkeys. Apomorphine treatment was found to result in higher rates of glucose utilization in the denervated striatum than in the intact hemisphere. Furthermore, the effect was more robust in the striosomes than in the matrix, thus providing evidence for differential functional and/or metabolic regulation in striatal striosomes and matrix in parkinsonian syndromes.
Insights
Apomorphine boosts glucose metabolism in the denervated striatum of MPTP-lesioned monkeys. This effect is stronger in striosomes than matrix, indicating distinct regulation in parkinsonian syndromes.
Area of Science:
- Neuroscience
- Neuropharmacology
- Metabolic studies
Background:
- Previous studies suggest differing regulatory mechanisms in striatal striosomes and matrix after dopaminergic input loss.
- Parkinsonian syndromes involve the degeneration of dopaminergic neurons, impacting striatal function.
Purpose of the Study:
- To investigate if apomorphine differentially affects glucose metabolism in striatal striosomes and matrix.
- To explore functional and metabolic regulation differences in striatal compartments during parkinsonian syndromes.
Main Methods:
- Utilized MPTP-lesioning in monkeys to create a parkinsonian model.
- Administered apomorphine to stimulate dopamine receptors.
- Measured and compared glucose utilization rates in striatal striosomes and matrix between hemispheres.
Main Results:
- Apomorphine treatment increased glucose utilization in the denervated striatum compared to the intact hemisphere.
- The increase in glucose utilization was more pronounced in the striosomes than in the matrix.
- These findings suggest differential metabolic responses within striatal compartments.
Conclusions:
- Apomorphine differentially modulates glucose metabolism in striatal striosomes and matrix in a parkinsonian model.
- Provides evidence for distinct functional and/or metabolic regulation in these striatal compartments during parkinsonian syndromes.
- Highlights the potential for compartment-specific therapeutic strategies in Parkinson's disease.